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Updated: Jun 25, 2026
Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
Light-activated thiomaleimide crosslinking stabilizes collagen mimetic peptide triple helix
Rafael A Castro1, Shashika Gammanchiralage2, Christopher Price3
1Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, USA. akloxin@udel.edu.
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Collagen mimetic peptides (CMPs) are useful self-assembling building blocks for creating tunable biomaterials with structure and function dependent on triple helix stability. We demonstrate rapid, UV-activated stabilization of a CMP triple helix via thiomaleimide self-crosslinking controlled by light dose, enabling precise in situ control and stabilization of peptide assemblies.
