Development, Characterization, and Cellular Toxicity Evaluation of Solid Dispersion-Loaded Hydrogel Based on...

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Dermatology

Background:

• Indomethacin (IND), a cyclooxygenase inhibitor, causes gastrointestinal issues with oral use.
• Topical IND faces challenges in skin permeation due to poor solubility and photodegradation.

Purpose of the Study:

• To develop indomethacin solid dispersions (SDs) with low-substituted hydroxypropyl cellulose (LHPC).
• To incorporate IND-SDs into hydroxypropyl guar (HPG) hydrogels for enhanced topical delivery.
• To evaluate the physicochemical properties and efficacy of the formulated hydrogels.

Main Methods:

• Solid dispersions (SDs) of IND with LHPC were prepared.
• IND-SDs were formulated into HPG hydrogels.
• Characterization included SEM, DSC, XRPD, FTIR, viscosity, drug release, and cytotoxicity assays.

Main Results:

• SEM revealed a porous structure in SD hydrogels.
• DSC and XRPD indicated the formation of amorphous IND species, enhancing drug release.
• FTIR confirmed hydrogen bonding, and viscosity increased in SD hydrogels.
• IND-SD hydrogels showed no skin irritation and suitable viscosity for dermal application.

Conclusions:

• Formulated IND-SD hydrogels improve indomethacin solubility and release for topical administration.
• The developed hydrogels offer a promising, safe, and effective alternative for topical IND delivery.