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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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  1. Home
  3. Interstitial Fibrosis As A Common Counterpart Of Histopathological Risk Factors In Papillary Thyroid Microcarcinoma: A Retrospective Analysis
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  3. Interstitial Fibrosis As A Common Counterpart Of Histopathological Risk Factors In Papillary Thyroid Microcarcinoma: A Retrospective Analysis

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Interstitial Fibrosis as a Common Counterpart of Histopathological Risk Factors in Papillary Thyroid Microcarcinoma:

Can Sahin1, Mehmet Arda Inan2, Banu Bilezikci3

  • 1Department of General Surgery, Yenimahalle Training and Research Hospital, Ankara 06370, Türkiye.

Diagnostics (Basel, Switzerland)
|August 10, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Interstitial fibrosis is linked to poorer prognostic factors in papillary thyroid microcarcinoma. This finding suggests interstitial fibrosis may serve as a risk factor for this cancer type.

Keywords:
interstitial fibrosispapillary cancer variantspapillary thyroid microcarcinomarisk factorsthyroid cancer prognosis

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Interstitial fibrosis is under-investigated in papillary thyroid microcarcinoma.
  • Understanding its role is crucial for assessing prognosis.

Purpose of the Study:

  • To determine the relationship between interstitial fibrosis and papillary microcarcinoma subtypes.
  • To investigate the association with established prognostic factors.

Main Methods:

  • Retrospective analysis of 75 papillary microcarcinoma cases.
  • Evaluation of demographic features, tumor characteristics, and histopathological findings.
  • Review of hematoxylin and eosin slides for interstitial fibrosis.

Main Results:

  • Interstitial fibrosis was present in 68% of patients.
  • Fibrosis significantly correlated with bilaterality, multifocality, capsule invasion, and lymph node metastasis.
  • Follicular variant showed increased risk of lymphovascular invasion.

    • Conclusions:

    • Interstitial fibrosis is associated with adverse prognostic factors in papillary microcarcinoma.
    • It may serve as a potential risk factor.
    • Further research is needed to elucidate its role in tumorigenesis.