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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Related Experiment Video

Updated: Jun 17, 2025

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
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Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention.

Patricia F Boothe1, Vidya P Kumar2, Yali Kong3

  • 1Department of Internal Medicine, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA 23507, USA.

International Journal of Molecular Sciences
|August 10, 2024
PubMed
Summary

Radiation therapy can cause skin fibrosis (RISF), a long-term complication affecting cancer survivors. Understanding the roles of reactive oxygen species (ROS) and angiotensin II (Ang II) may lead to better treatments for this condition.

Keywords:
AT1Rangiotensin II (Ang II)radiationreactive oxygen species (ROS)skin fibrosistelmisartan

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Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Radiation therapy improves cancer survival but can cause radiation-induced skin fibrosis (RISF).
  • RISF presents significant physical and psychological challenges for cancer survivors.
  • Approximately 50% of patients undergoing radiation therapy may achieve long-term remission, increasing the population managing treatment aftereffects.

Purpose of the Study:

  • To explore the relationship between radiation-induced skin fibrosis (RISF), reactive oxygen species (ROS), and angiotensin II (Ang II) signaling.
  • To propose underlying mechanisms of RISF development.
  • To examine potential therapeutic strategies for mitigating skin fibrosis.

Main Methods:

  • Literature review and analysis of existing research on RISF.
  • Examination of the molecular pathways involving ROS and Ang II in fibrogenesis.
  • Synthesis of current understanding to propose treatment avenues.

Main Results:

  • RISF is a complex condition linked to long-term radiation exposure.
  • ROS and Ang II signaling pathways are implicated in the development of skin fibrosis.
  • Understanding these mechanisms is crucial for developing effective interventions.

Conclusions:

  • Targeting ROS and Ang II signaling pathways may offer novel therapeutic strategies for RISF.
  • Improved management of RISF can enhance the quality of life for cancer survivors.
  • Further research is needed to translate these insights into clinical practice.