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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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[Infectious mononucleosis : an atypical cause of acute alithiasic cholecystitis]

Coumba Diop1, Marie Pironet2, Julie Descy1

  • 1Laboratoire de Biologie Clinique, Clinique André Renard, Herstal, Belgique.

Revue Medicale De Liege
|August 12, 2024
PubMed

Insights

Epstein-Barr virus (EBV) can cause a rare gallbladder inflammation called acute acalculous cholecystitis. Early diagnosis involves correlating imaging with liver function and white blood cell tests.

Area of Science:

  • Virology
  • Gastroenterology
  • Hepatology

Background:

  • Epstein-Barr virus (EBV) is a widespread herpesvirus, commonly causing infectious mononucleosis.
  • Infectious mononucleosis typically presents asymptomatically or with fever, pharyngitis, and lymphadenopathy.
  • Acute acalculous cholecystitis is a rare gallbladder inflammation without gallstones, often linked to ischemia and cholestasis.

Observation:

  • A case study of a 21-year-old woman presenting with acute acalculous cholecystitis is detailed.
  • The patient's presentation highlights a less common manifestation of EBV infection.
  • Diagnostic challenges in determining the etiology of acute acalculous cholecystitis are noted.

Findings:

  • The case underscores acute acalculous cholecystitis as a rare complication of Epstein-Barr virus infection.
  • Interpreting liver function tests and leukocyte counts alongside imaging is crucial for diagnosis.
  • EBV-associated cholecystitis may be an under-recognized clinical entity.

Implications:

  • This case emphasizes the importance of considering EBV in the differential diagnosis of acute acalculous cholecystitis.
  • Clinicians should integrate laboratory findings with imaging to improve diagnostic accuracy for this rare complication.
  • Further research may elucidate the mechanisms and prevalence of EBV-induced gallbladder inflammation.
Keywords:
Acalculous cholecystitisCholecystectomyEBVInfection

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