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Related Experiment Video

Updated: May 1, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Patent Foramen Ovale Closure for Nonstroke Indications.

Akilesh P Honasoge1, Hussam S Suradi1, Jonathan M Tobis2

  • 1Division of Cardiology, Department of Medicine, Rush University Medical Center, Chicago, Illinois.

Journal of the Society for Cardiovascular Angiography & Interventions
|August 12, 2024
PubMed
Summary

Patent foramen ovale (PFO) closure effectively reduces recurrent strokes in select patients. While PFO closure is increasingly used for cryptogenic stroke, its efficacy in other conditions requires further investigation.

Keywords:
decompressionillnessliver transplantationmigraines with aurapatent foramen ovale closureplatypnea-orthodeoxia syndrome

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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
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Area of Science:

  • Cardiology
  • Neurology
  • Interventional Cardiology

Background:

  • Patent foramen ovale (PFO) is an atrial septum defect present in 20-34% of adults.
  • While often benign, PFO can enable paradoxical emboli, linking it to cryptogenic stroke, migraines, and decompression illness.

Purpose of the Study:

  • To review current data and management strategies for PFO closure in conditions beyond cryptogenic stroke.
  • To explore potential indications for PFO closure in various clinical scenarios.

Main Methods:

  • Review of existing clinical data and randomized control trials on PFO closure.
  • Analysis of procedural success and complication rates for PFO closure procedures.

Main Results:

  • PFO closure significantly reduces recurrent stroke rates compared to medical therapy in cryptogenic stroke patients.
  • Worldwide PFO closure procedures have increased, primarily for cryptogenic stroke, with high success and low complication rates.

Conclusions:

  • Percutaneous PFO closure is a proven therapy for carefully selected cryptogenic stroke patients.
  • Evidence supporting PFO closure for other conditions is currently lacking, necessitating further research.