Related Experiment Video
Updated: Jun 17, 2025
05:41
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
566
Translating thyroid hormone into clinical practice: lessons learned from the post-hoc analysis on data available from
Constantinos I Pantos1, Konstantinos P Grigoriou2, Athanasios G Trikas2
1Department of Pharmacology, National and Kapodistrian University of Athens, Athens, Greece.
Frontiers in Endocrinology
|August 12, 2024
Summary
Thyroid hormone (TH) treatment showed improved cardiac function recovery in patients with larger heart attack sizes. This suggests potential benefits for myocardial edema and microvascular obstruction, warranting further large-scale studies.
Area of Science:
- Cardiology
- Endocrinology
- Regenerative Medicine
Background:
- Thyroid hormone (TH) demonstrates potential reparative effects on postinfarcted myocardium.
- The ThyRepair trial investigated this novel action in a pilot, randomized, double-blind, placebo-controlled setting.
- This study presents a post-hoc analysis of ThyRepair data to further elucidate TH's effects on human postischemic myocardium.
Purpose of the Study:
- To investigate the effects of triiodothyronine (LT3) on cardiac function and structure after myocardial infarction.
- To analyze cardiac magnetic resonance imaging (CMR) data from the ThyRepair study.
- To explore potential differences in treatment effects based on infarct size.
Main Methods:
- A post-hoc analysis of 41 patients from the ThyRepair study (20 placebo, 21 LT3).
- LT3 administered intravenously for 48 hours post-stenting.
- Cardiac magnetic resonance (CMR) assessed left ventricular ejection fraction (LVEF%), end-diastolic volume index (LVEDVi), end-systolic volume index (LVESVi), infarct volume (IV), left ventricular mass index (LVMi), and microvascular obstruction (MVO) at discharge.
Main Results:
- In patients with large infarcts (IV > 20%), LT3 treatment significantly improved LVEF% (47.3 ± 6.5 vs. 39.9 ± 8.7, p < 0.05) and reduced LVEDVi and LVESVi compared to placebo.
- No significant differences in LVEF%, LVEDVi, or LVESVi were observed between LT3 and placebo groups in patients with smaller infarcts (IV ≤ 20%).
- A trend towards lower LVMi and MVO was observed in the LT3 group, though not statistically significant.
Conclusions:
- Acute LT3 treatment may enhance cardiac function recovery, particularly in patients with larger infarct sizes.
- LT3 shows a potential beneficial effect on myocardial edema and microvascular obstruction post-infarction.
- These findings support further investigation in larger clinical trials to confirm the therapeutic potential of LT3.
Related Concept Videos
01:20Synthesis and Regulation of Thyroid Hormones
4.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.4K
01:18Functions of Thyroid Hormones
2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.6K
01:23The Thyroid Gland
3.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.7K
01:16Clinical Trials
6.6K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.6K
01:22Target Cell Response to Hormones
3.0K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
3.0K
01:17Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K