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Research trends of next generation probiotics
Muhammad Adeel Hasnain1, Dae-Kyung Kang2, Gi-Seong Moon1,3,4
1Major in IT·Biohealth Convergence, Department of IT·Energy Convergence, Graduate School, Korea National University of Transportation, Chungju, 27469 Republic of Korea.
Food Science and Biotechnology
|August 12, 2024
Summary
Next generation probiotics, developed using advanced omics technologies, offer targeted solutions for gut dysbiosis and related health conditions. These tailor-made probiotics show promise for specific diseases and consumer needs.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- The gut microbiota plays a crucial role in host health, influencing metabolism, immunity, and disease protection.
- Microbial imbalance (dysbiosis) is linked to various intestinal, systemic, metabolic, and neurodegenerative disorders.
- Traditional probiotics aim to restore gut balance, but next generation probiotics offer more targeted therapeutic potential.
Purpose of the Study:
- To review recent advancements in next generation probiotics.
- To discuss the potential of tailor-made probiotics in addressing specific health conditions.
- To identify challenges in translating next generation probiotic concepts into clinical reality.
Main Methods:
- Review of current scientific literature on next generation probiotics.
- Analysis of omics technologies (high-throughput sequencing, bioinformatics) enabling probiotic development.
- Discussion of mechanistic studies and clinical applications.
Main Results:
- Next generation probiotics are being developed using advanced technologies for specific health benefits.
- These bespoke probiotics show potential for ameliorating targeted disease conditions.
- Significant progress has been made in understanding the mechanisms of next generation probiotics.
Conclusions:
- Next generation probiotics represent a promising frontier in microbiome-based therapeutics.
- Tailor-made probiotics have the potential to meet specific consumer health needs.
- Overcoming current challenges is crucial for the successful clinical translation of next generation probiotics.
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