Poor Patient-Reported Outcomes and Impaired Work Productivity in Patients With Inflammatory Bowel Disease in...

Area of Science:

• Gastroenterology
• Clinical Research
• Health Outcomes

Background:

• Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), significantly impacts patients' quality of life.
• Understanding the relationship between disease severity, patient-reported outcomes (PROs), and work productivity is crucial for comprehensive IBD management.

Purpose of the Study:

• To evaluate the associations between IBD disease severity and patient-reported outcomes.
• To assess the impact of IBD on work productivity and daily activity impairment.
• To identify unmet needs in IBD patient care regarding psychosocial function and work capacity.

Main Methods:

• A real-world analysis of 1543 IBD patients (812 CD, 731 UC) from the CorEvitas IBD Registry (May 2017-September 2019).
• Disease severity assessed using the Harvey-Bradshaw Index (CD) and partial Mayo Score (UC).
• Psychosocial PROs (PROMIS) and work productivity (WPAI) were evaluated using regression analyses.

Main Results:

• A significant proportion of IBD patients, including those in remission, reported impaired psychosocial function (e.g., fatigue, depression) and reduced work productivity.
• For CD patients in remission, 54.3% reported work productivity loss and 57.1% activity impairment.
• For UC patients in remission, 43.5% reported activity impairment, and scores for psychosocial outcomes and work productivity worsened with increasing disease severity.

Conclusions:

• IBD patients, irrespective of disease activity level, experience substantial impairment in psychosocial well-being and work productivity.
• Even patients in remission demonstrate significant deficits, underscoring an unmet need for improved therapeutic and supportive strategies.
• These findings emphasize the systemic impact of IBD beyond gastrointestinal symptoms, necessitating a holistic approach to patient care.