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Cardiology Assessment of Patients Undergoing Evaluation for Orthotopic Liver Transplantation
Michael S Lee1, Subeer Wadia1, Yerem Yeghiazarians2
1Division of Cardiology, University of California, Los Angeles Medical Center, Los Angeles, California.
Insights
Cardiovascular disease screening before orthotopic liver transplantation (OLT) is crucial for patient outcomes. Noninvasive methods are recommended for assessing cardiovascular risk, with invasive strategies reserved for select patients.
Area of Science:
- Cardiology
- Hepatology
- Transplant Surgery
Background:
- Orthotopic liver transplantation (OLT) is a critical treatment for end-stage liver disease.
- Patients undergoing OLT face significant cardiovascular stress due to hemodynamic changes and prolonged surgery.
- Pre-transplant cardiovascular disease diagnosis and management are vital for successful outcomes.
Purpose of the Study:
- To examine the diagnostic cardiovascular workup for OLT candidates.
- To review current literature on diagnostic modalities for pre-OLT cardiovascular disease screening.
- To advocate for evidence-based, standardized cardiovascular risk assessment protocols.
Main Methods:
- Literature review of diagnostic modalities for cardiovascular disease in OLT candidates.
- Collaboration with cardiology and hepatology experts from leading OLT centers.
- Analysis of existing institutional protocols and their adherence to evidence.
Main Results:
- Significant variability exists in current pre-OLT cardiovascular screening practices.
- Noninvasive diagnostic methods are effective for assessing cardiovascular risk in most OLT candidates.
- Invasive risk stratification should be reserved for specific, high-risk patient subgroups.
Conclusions:
- Standardized, evidence-based cardiovascular screening protocols are needed for OLT candidates.
- Emphasis should be placed on noninvasive diagnostic approaches to optimize patient selection and outcomes.
- Further research may refine risk stratification and improve perioperative management.
Abstract:
Orthotopic liver transplantation (OLT) is a viable treatment option for end-stage liver disease. Significant perioperative stress is placed on the cardiovascular system because of hemodynamic changes and the length of the operation. Diagnosis and treatment of cardiovascular disease before OLT are imperative to ensure favorable outcomes. Considerable variability exists among practitioners caring for these patients. Institutions tailor their protocols on the basis of local and historical practices, the preferences of the cardiologists, and the OLT team, and algorithms are not often revised or updated on the basis of the available evidence. In collaboration with cardiology and hepatology experts from leading OLT centers, we sought to examine the diagnostic cardiovascular workup of OLT candidates, including a review of the available literature on the diagnostic modalities used to screen cardiovascular disease before OLT. We advocate an emphasis on noninvasive methods to assess cardiovascular risk with reserved use of invasive risk stratification in select patients.
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