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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
222
LncRNA-encoded peptides in cancer
1Laboratory of Gastrointestinal Tumor Epigenetics and Genomics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China. zhangyaguang20085155@126.com.
Journal of Hematology & Oncology
|August 12, 2024
Summary
Long non-coding RNAs (lncRNAs) can encode peptides that play roles in cancer. This review covers their detection, functions, and potential as cancer biomarkers and therapeutics.
Area of Science:
- Molecular Biology
- Cancer Research
- Genomics
Background:
- Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial regulators of gene expression.
- Emerging evidence shows lncRNAs can encode small peptides, influencing cancer development and progression.
Purpose of the Study:
- To review the current understanding of lncRNA-encoded peptides in cancer.
- To explore their detection, functional roles, and clinical significance.
Main Methods:
- Discusses technological advancements for detecting and validating small open reading frames (sORFs) and their encoded peptides.
- Includes ribosome profiling and mass spectrometry.
Main Results:
- lncRNA-encoded peptides are involved in key cancer processes like transcription, translation, signaling, and metabolism.
- These peptides show potential as diagnostic biomarkers, prognostic indicators, and therapeutic targets.
Conclusions:
- lncRNA-encoded peptides represent a promising area for cancer diagnostics and therapeutics.
- Further research is needed for validation, improved detection, and optimized therapeutic strategies.
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