Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Longitudinal Studies

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Foundations of Gerophysics.

Aging·2026

Same author

A metabolic atlas of mouse aging.

Cell metabolism·2025

Same author

Open problems in ageing science: a roadmap for biogerontology.

GeroScience·2025

Same author

Benchmarking large language models for personalized, biomarker-based health intervention recommendations.

NPJ digital medicine·2025

Same author

DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders.

Aging·2025

Same author

Innovations in aging biology: highlights from the ARDD emerging science & technologies workshop.

npj aging·2025

Same journal

Editorial: Microbial influences on aging: insights from the gut microbiome.

Frontiers in aging·2026

Same journal

Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions.

Frontiers in aging·2026

Same journal

Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.

Frontiers in aging·2026

Same journal

Acute changes in ankle dorsiflexor strength and fNIRS-Derived cortical activation following a single session of neuromuscular electrical stimulation in healthy older adults.

Frontiers in aging·2026

Same journal

Senescent fibroblasts in aging and pulmonary fibrosis.

Frontiers in aging·2026

Same journal

Beyond chronological age: frailty, vitality, and subjective health structured by psychological segmentation in older adults.

Frontiers in aging·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

Advancing longevity research through decentralized science.

Maximilian Unfried^1,2

¹Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Frontiers in Aging

|August 13, 2024

Summary

This summary is machine-generated.

Decentralized Science (DeSci) uses blockchain to improve research funding and publishing, making science more transparent and efficient. This approach can accelerate progress, especially in critical fields like longevity science.

Keywords:

aging biotech blockchain crypto decentralized science longevity open source

More Related Videos

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

Related Experiment Videos

Last Updated: Jun 17, 2025

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

Area of Science:

Scientific research methodology
Biotechnology and biomedical engineering
Blockchain technology applications

Background:

Traditional scientific funding and publishing face inefficiencies and stagnation.
Centralized academic institutions may slow down scientific progress.
Aging is a primary risk factor for numerous diseases, highlighting the need for advancements in longevity science.

Purpose of the Study:

To introduce Decentralized Science (DeSci) as a novel framework for scientific research.
To explore how DeSci can address inefficiencies in traditional academic systems.
To examine the potential impact of DeSci on the field of longevity science.

Main Methods:

Utilizing blockchain technology for decentralized research funding and publishing.
Implementing decentralized autonomous organizations (DAOs) for community-driven initiatives.
Promoting transparency, open-source principles, and rapid funding mechanisms.

Main Results:

DeSci offers a potential solution to misaligned incentives in academic research.
The model emphasizes transparency, speed, and open collaboration.
DeSci can foster high-risk, high-reward research, particularly in areas like longevity.

Conclusions:

Decentralized Science (DeSci) presents a transformative model for scientific advancement.
DeSci can overcome the limitations of centralized systems, accelerating progress.
The integration of DeSci, especially in longevity research, promises a more equitable and efficient scientific future.