Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.1K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.1K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

657
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
657

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine learning-guided design of cooperative multi-size hydrogel microspheres for osteoarthritis therapy.

Biomaterials·2026
Same author

Galla Chinensis Polyphenol-Loaded Hemostatic Granules for Rapid Hemostasis, Antibacterial Action, and Wound Healing Promotion.

Journal of functional biomaterials·2026
Same author

A sulfated chitosan-driven immune-ECM reprogramming strategy to break the vicious cycle of aged wound healing.

Bioactive materials·2026
Same author

A sustained NAD<sup>+</sup> supplementation-biosynthesis nanoplatform for metabolic restoration in aged bone regeneration.

Bioactive materials·2026
Same author

Superhydrophobic Wearable Strain Sensors: From Strategic Design to Robustness Paradigm.

Nano-micro letters·2026
Same author

Glycosaminoglycan-Mimetic Sulfated Chitosan Promotes Extracellular Matrix Formation and Regulates Inflammation to Alleviate Osteoarthritis.

Bioengineering (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 17, 2025

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.6K

Calcium Ion-Coupled Polyphosphates with Different Degrees of Polymerization for Bleeding Control.

Laiqiang Tong1, Dong Zhang1, Zhenhua Huang1

  • 1Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, P. R. China.

ACS Applied Materials & Interfaces
|August 13, 2024
PubMed
Summary

Calcium ion-coupled polyphosphate (CaPP) powders were synthesized to investigate the effect of polyphosphate chain length on hemostasis. CaPP-50 demonstrated superior hemostatic performance, accelerating blood clotting and clot stabilization for effective hemorrhage control.

Keywords:
CaPP-50biocompatibilitycalcium ionhemostasispolymerization degreepolyphosphate

More Related Videos

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.1K
Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

19.1K

Related Experiment Videos

Last Updated: Jun 17, 2025

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.6K
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.1K
Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

19.1K

Area of Science:

  • Biomaterials Science
  • Hemostasis Research
  • Materials Chemistry

Background:

  • Efficient hemostatic materials are critical for controlling bleeding and promoting wound healing.
  • Inorganic polyphosphate (polyP) modulates blood coagulation, but its chain length effects require further investigation.
  • Calcium ions (Ca2+) are vital for coagulation cascade enzyme activity.

Purpose of the Study:

  • To synthesize and characterize calcium ion-coupled polyphosphate (CaPP) powders with varying polymerization degrees (n=20, 50, 1500).
  • To evaluate the influence of polyP chain length on hemostatic efficacy.
  • To assess the potential of CaPP as an active inorganic hemostatic agent.

Main Methods:

  • Ion-exchange reaction to synthesize CaPP powders with n=20, 50, and 1500.
  • Characterization of CaPP phase transitions (crystalline to amorphous) with increasing polymerization.
  • In vitro assessment of hemostatic performance using blood clotting index (BCI) and clotting time.
  • In vivo validation using rat liver bleeding and femoral artery puncture models.

Main Results:

  • CaPP powders were successfully synthesized, exhibiting phase transitions with increasing polymerization degree.
  • CaPP enhanced polyP wettability and demonstrated chain-length-dependent hemostatic activity.
  • CaPP-50 exhibited the most potent hemostasis, with the lowest BCI (12.1 ± 0.7%) and shortest clotting time (302.0 ± 10.5 s).
  • CaPP-50 accelerated blood cell adhesion/activation, initiated the intrinsic coagulation cascade, and formed stable clots.
  • In vivo studies confirmed CaPP-50's efficacy, comparable to commercial hemostatic powders and superior to kaolin.
  • CaPP-50 demonstrated excellent biocompatibility and storage stability.

Conclusions:

  • CaPP-50, a medium-chain polyphosphate coupled with calcium ions, significantly enhances hemostasis.
  • CaPP-50's mechanism involves promoting blood cell activity and stabilizing clot formation.
  • CaPP-50 shows promising potential as a clinically viable inorganic hemostatic agent for rapid bleeding control.