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Dapsone resistance in North India
Indian Journal of Leprosy
|July 1, 1985
Abstract:
An attempt has been made to screen the resistant strains of M. leprae in lepromatous patients from the eight northern States of India. By using the mouse foot pad technique it was found that in a total of 69 clinically suspected patients 33 (47.8%) harboured M. leprae with some degree of dapsone resistance. A detailed epidemiological study in these parts of the country may reveal the prevalence rate.
Insights
Researchers screened leprosy patients in Northern India for dapsone-resistant Mycobacterium leprae. Nearly half of suspected cases showed resistance, highlighting the need for further epidemiological studies on drug resistance in leprosy.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Dermatology
Background:
- Leprosy, caused by Mycobacterium leprae, remains a public health concern.
- Drug resistance, particularly to dapsone, can complicate treatment and disease control.
- Northern India is a region with a significant leprosy burden.
Purpose of the Study:
- To screen for dapsone-resistant Mycobacterium leprae in lepromatous leprosy patients.
- To assess the prevalence of drug resistance in a specific geographic area of India.
Main Methods:
- Utilized the mouse foot pad technique for detecting Mycobacterium leprae.
- Screened clinically suspected lepromatous leprosy patients from eight northern Indian states.
Main Results:
- Identified Mycobacterium leprae in 69 clinically suspected patients.
- Found that 33 out of 69 patients (47.8%) harbored Mycobacterium leprae with dapsone resistance.
Conclusions:
- A significant proportion of leprosy patients in Northern India exhibit dapsone resistance.
- Further epidemiological studies are warranted to determine the precise prevalence of drug resistance in this region.