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Dapsone resistance in North India.

Sreevatsa, B K Girdhar, G Ramu

Indian Journal of Leprosy

|July 1, 1985

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Researchers screened leprosy patients in Northern India for dapsone-resistant Mycobacterium leprae. Nearly half of suspected cases showed resistance, highlighting the need for further epidemiological studies on drug resistance in leprosy.

Area of Science:

Medical Microbiology
Infectious Diseases
Dermatology

Background:

Leprosy, caused by Mycobacterium leprae, remains a public health concern.
Drug resistance, particularly to dapsone, can complicate treatment and disease control.
Northern India is a region with a significant leprosy burden.

Purpose of the Study:

To screen for dapsone-resistant Mycobacterium leprae in lepromatous leprosy patients.
To assess the prevalence of drug resistance in a specific geographic area of India.

Main Methods:

Utilized the mouse foot pad technique for detecting Mycobacterium leprae.
Screened clinically suspected lepromatous leprosy patients from eight northern Indian states.

Main Results:

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Identified Mycobacterium leprae in 69 clinically suspected patients.
Found that 33 out of 69 patients (47.8%) harbored Mycobacterium leprae with dapsone resistance.

Conclusions:

A significant proportion of leprosy patients in Northern India exhibit dapsone resistance.
Further epidemiological studies are warranted to determine the precise prevalence of drug resistance in this region.