Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases

Evidence suggests an association between periodontitis and neurodegenerative diseases, but a comprehensive analysis of research trends remains absent. Therefore, we aim to identify research trends and hotspots on the comorbidity between periodontitis and neurodegenerative diseases, understand mechanisms, provide guidance for subsequent studies and show its clinical translational possibility.

A bibliometric analysis covering 1982 to 2023 was conducted using the Web of Science Core Collection. English-language articles range from January 1, 1982 to November 30, 2023 were analyzed. Data were downloaded on November 30, 2023 and analyzed on December, 2023. Data visualization and statistical analysis were performed to identify trends of annual publications, countries, sources, institutions, authors, most cited articles, and keywords by using Microsoft Excel, VOSviewer, Citespace, R-bibliometrix and Origin Pro.

A total of 1,238 articles from 1982 to 2023 on the comorbidity between periodontitis and neurodegenerative diseases were identified. Annual publications showed an upward trend. The United States, University College of London, BRAIN and Shy, Michael E. were the leading nation, affiliation, source and author, respectively. The United States, NEUROLOGY, and Curtis Maurice A. were the most cited nation, source, and author. Keywords network analysis highlighted 'Charcot-Marie-Tooth Disease', 'Alzheimer's Disease' and 'Periodontitis' as focal points. Detection of keywords citation bursts demonstrated 'Porphyromonas gingivalis' and 'Cognitive Dysfunction' as hot topics in recent research.

In recent years, emerging interests of the comorbidity between periodontitis and neurodegenerative diseases (NDs) are growing. Our study enhances the understanding of recent research trends of periodontitis and NDs and provides valuable perspectives within this expanding field, offering new insights into research trends regarding the interplay between 'Porphyromonas gingivalis' and 'Cognitive Dysfunction'. Further research of the molecular mechanisms between P. gingivalis-induced periodontitis, neuroinflammation, that leads neurodegeneration are clearly warranted.