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Updated: Jul 16, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Rapidly progressive coronary atherosclerosis in a young male: a retrospective advanced CCT phenotype analysis

Daniel Lorenzatti1, Annalisa Filtz1,2, Azeem Latib1

  • 1Cardiology Division, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210st Bronx, Bronx, NY, 10467, USA.

The International Journal of Cardiovascular Imaging
|August 14, 2024
PubMed

Insights

Zero coronary calcium scores may be unreliable in young, high-risk patients. This case highlights rapid progression to severe coronary artery disease, emphasizing the need for comprehensive risk assessment beyond calcium scoring.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Preventive Cardiology

Background:

  • Coronary artery disease (CAD) risk stratification typically relies on coronary artery calcium (CAC) scoring.
  • Non-calcified plaque, though often less emphasized in risk assessment, can drive rapid disease progression.
  • Certain high-risk subgroups may present challenges to traditional risk stratification methods.

Keywords:
CCTACoronary artery diseaseFHFamiliar hypercholesterolemiaPlaqueYoung

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