Assessing metabolic flexibility response to a multifibre diet: a randomised-controlled trial

Area of Science:

• Nutrition Science
• Metabolic Health
• Dietary Interventions

Background:

• Metabolic flexibility (MetF) is crucial for evaluating dietary intervention effectiveness.
• Previous research indicated multifibre bread improves insulin sensitivity and lowers LDLc.
• This study investigated multifibre bread's effect on MetF.

Purpose of the Study:

• To assess the impact of multifibre bread on metabolic flexibility.
• To explore potential determinants of metabolic flexibility response.

Main Methods:

• A double-blind, randomized, crossover trial with 39 participants.
• Consumption of standard vs. multifibre bread for 8 weeks.
• Metabolic flexibility assessed via mixed-meal tolerance test (MMTT) and indirect calorimetry (measuring ∆RQ).

Main Results:

• No significant difference in ∆RQ between diets.
• Baseline ∆RQ correlated positively with postprandial triglyceride excursion (∆TG).
• MetF responders showed higher baseline LDLc and greater post-MMTT ∆TG.

Conclusions:

• Dietary fibres did not directly alter MetF in this cohort.
• Baseline lipid profiles may indicate individuals who will respond to MetF interventions.
• Further research is needed to confirm these determinants of MetF response.