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[Hyaluronan receptors: role in aging and age-associated processes.]
V N Khabarov1, A O Drobintseva2,3, T V Kvetnaya4
1Scientific Research Center of Hyaluronic Acid, 38/16 Komsomolsky pr., Moscow 119146, Russian Federation.
Advances in Gerontology = Uspekhi Gerontologii
|August 14, 2024
Summary
Hyaluronic acid receptors like CD44 are key in aging and cancer. Their roles in inflammation (inflamaging) and diseases like heart disease and osteoarthritis highlight their importance in health and disease.
Area of Science:
- Biomedical Science
- Molecular Biology
- Immunology
Background:
- Hyaluronic acid (HA) receptors are crucial for cellular processes.
- Dysregulation of HA signaling is implicated in aging and disease.
Purpose of the Study:
- To review the multifaceted roles of hyaluronic acid receptors.
- To elucidate their involvement in aging, inflamaging, and cancer development.
Main Methods:
- Literature review of studies on hyaluronic acid receptors.
- Analysis of in vivo and in vitro experimental data.
Main Results:
- CD44 receptor activation is linked to immune cells, coronary heart disease, and osteoarthritis (via TLR2/TLR4).
- RHAMM receptor shows oncogenic potential in various cancers, especially metastatic tumors.
- Specific HA fragments (4-25 disaccharides) promote lymphatic endothelial cell proliferation and lymphangiogenesis.
Conclusions:
- Hyaluronic acid receptors significantly influence aging by regulating inflamaging.
- These receptors are critical in the pathogenesis of malignant neoplasms.
- Targeting HA receptors may offer therapeutic strategies for age-related diseases and cancer.
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