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Updated: Jun 17, 2025
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Electrooxidative 1,3-Oxo/Carboamination of Arylcyclopropanes
Ziyan Chen1, Shuaishuai Zhao1, Tiantian Wang1
1Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), State Key Laboratory of Material-Oriented Chemical Engineering, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
Abstract:
Herein, the work demonstrates an electrochemically paired electrolysis approach facilitating the efficient achievement of the electrooxidative 1,3-oxo/carboamination of arylcyclopropanes under mild conditions. The formation of 1,3-arylamination of arylcyclopropanes involves commercially available amine redox mediators through a radical-radical process. In addition, the successful execution of β-amino ketones also occurs under atmospheric conditions. The control experiments supported the existence of key benzylic radical intermediates in the reaction pathway.
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