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Updated: Jun 17, 2025
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Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery
Published on: May 4, 2022
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Breast cancer localization by iodine seed 125I vs. wire- -guided localization - retrospective case-control study
Summary
Iodine seeds offer a promising alternative for localizing non-palpable breast tumors, resulting in smaller resections and fewer repeat surgeries compared to traditional wire-guided localization.
Area of Science:
- Oncology
- Radiology
- Surgical Pathology
Background:
- Wire-guided localization has been the standard for non-palpable malignant breast tumors.
- Modern localization techniques are increasingly replacing the wire-guided method.
Purpose of the Study:
- To compare the efficacy of iodine-125 seeds versus wire-guided localization for non-palpable breast tumors.
- To evaluate differences in resected tissue volume and resection margins between the two techniques.
Main Methods:
- Retrospective case-control study involving 62 patients with breast carcinoma.
- Comparison of iodine-125 seed localization (31 patients) and wire-guided localization (31 patients).
Main Results:
- Iodine-125 seed group had significantly smaller resected tissue volume (46.2 cm3) than wire-guided group (83.7 cm3).
- R0 resection rates were higher in the iodine-125 seed group (93.5%) compared to the wire-guided group (77.4%).
- Re-resection due to positive margins was significantly lower in the iodine-125 seed group (0%) versus the wire-guided group (19.4%).
Conclusions:
- Iodine-125 seed localization is associated with reduced resected tissue volume compared to wire-guided localization.
- A trend towards improved R0 resection rates and a significant reduction in re-resections were observed with iodine-125 seeds.
