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Management of Chronic Heart Failure with Reduced Ejection Fraction

Brandon Williamson1, Carl Tong2

  • 1From the Texas A&M University Health Science Center, Bryan, TX (BW); Texas A&M University Health Science Center, Bryan, TX (CT). Bwilliamson@tamu.edu.

Journal of the American Board of Family Medicine : JABFM
|August 14, 2024
PubMed

Insights

This review covers guideline-directed medical therapy for heart failure with reduced ejection fraction (HFrEF). It details established treatments and newer options like sacubitril-valsartan and SGLT2 inhibitors for chronic HFrEF management.

Area of Science:

  • Cardiology
  • Pharmacology
  • Family Medicine

Background:

  • Heart failure with reduced ejection fraction (HFrEF) is a prevalent condition encountered in family practice.
  • Effective pharmacologic management is crucial for improving patient outcomes and quality of life.

Purpose of the Study:

  • To provide a comprehensive overview of the pharmacologic management of chronic HFrEF.
  • To highlight the latest American Heart Association guidelines for guideline-directed medical therapy (GDMT).

Main Methods:

  • Review of current literature and clinical guidelines.
  • Detailed discussion of established and emerging pharmacologic agents for HFrEF.
  • Focus on classification, GDMT, and comorbidity management.

Main Results:

  • Established therapies including beta-blockers, ACE inhibitors, ARBs, and MRAs remain foundational.
  • Newer agents such as sacubitril-valsartan and SGLT2 inhibitors represent significant advancements in HFrEF treatment.
  • Comprehensive management also involves addressing comorbidities and considering advanced therapies.

Conclusions:

  • Adherence to GDMT, incorporating novel therapies, is essential for optimal HFrEF care.
  • Family physicians play a key role in managing chronic HFrEF with evidence-based pharmacologic strategies.
  • Continuous updates in treatment recommendations necessitate ongoing professional development in HFrEF management.

Keywords:
Heart Failure with Reduced Ejection FractionPharmacotherapy

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