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Changes in Brain Functional Connectivity Underlying the Space-Number Association.

Stefano Lasaponara1,2, Mario Pinto1,2, Silvana Lozito1

  • 1"Sapienza" Università di Roma.

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|August 15, 2024
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This summary is machine-generated.

The space-number association (SNA) is not inherent but emerges from top-down brain control. Mathematical cognition relies on how the brain integrates number magnitudes and spatial information, not innate spatial coding.

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Area of Science:

  • Cognitive Neuroscience
  • Mathematical Cognition
  • Neuroimaging

Background:

  • The space-number association (SNA) proposes that smaller numbers are mentally represented to the left of larger numbers.
  • Investigating the neural underpinnings of SNA is crucial for understanding mathematical cognition.

Purpose of the Study:

  • To investigate brain activity and functional connectivity related to SNA using fMRI.
  • To determine if SNA is an inherent, bottom-up process or a result of top-down control.

Main Methods:

  • fMRI study employing a go/no-go implicit association task with Arabic digits and arrows.
  • Two conditions: single-code task and joint-code (JC) task with congruent and incongruent instructions.
  • Analysis of brain activity and functional connectivity, specifically focusing on the intraparietal sulcus (IPS).

Main Results:

  • SNA was observed only in the JC condition, with faster responses to congruent instructions.
  • fMRI connectivity revealed enhanced excitatory inputs to the left and right IPS from ACC, left TPJ, and left inferior frontal gyrus during SNA.
  • Incongruent JC trials showed increased excitatory modulation from ACC to the IPS.

Conclusions:

  • SNA is not based on inherent, bottom-up spatial coding of number magnitudes.
  • SNA is associated with top-down brain control mechanisms and altered functional interactions within the IPS.
  • These findings highlight the role of cognitive control in the spatial representation of numbers.