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Updated: Jul 11, 2026
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Biomimetic Nanoparticles for the Diagnosis and Therapy of Atherosclerosis
Yan Wang1, Yize Li2, Yuqing Lu2
1The First Clinical Medical College, Xuzhou Medical University, Xuzhou, 221004, China.
Insights
Biomimetic nanoparticles (BNPs) show promise for diagnosing and treating atherosclerosis (AS). This review explores BNPs derived from key cells involved in AS, highlighting their diagnostic and therapeutic potential for cardiovascular events.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Nanotechnology
Background:
- Atherosclerosis (AS) is a chronic inflammatory vascular disease often asymptomatic early on.
- AS can lead to lumen blockage, plaque rupture, thrombosis, and severe cardiovascular events.
- Early recognition and precise therapy of atherosclerotic plaques are crucial.
Purpose of the Study:
- To review the roles of key cells in AS progression.
- To discuss the construction of cell membrane-coated biomimetic nanoparticles (BNPs) for AS.
- To summarize the applications of BNPs in AS diagnosis and therapy.
Main Methods:
- Literature review focusing on AS pathogenesis and biomimetic nanoparticle development.
- Analysis of cell membrane-derived nanoparticles for targeting AS.
- Evaluation of diagnostic and therapeutic strategies utilizing BNPs.
Main Results:
- BNPs, particularly cell membrane-coated ones, leverage cellular functions for AS applications.
- Various cell types are key in AS progression and can serve as sources for BNPs.
- BNPs demonstrate potential in both diagnosing and treating AS.
Conclusions:
- Biomimetic nanoparticles offer a promising avenue for advancing atherosclerosis diagnosis and treatment.
- Further research into BNP construction and application is needed for clinical translation.
- Optimizing BNPs could significantly improve the management of cardiovascular diseases.
Abstract:
Atherosclerosis (AS) is a chronic inflammation of blood vessels, which often has no obvious symptoms in the early stage of the disease, but when atherosclerotic plaques are formed, they often cause lumen blockage, and even plaque rupture leads to thrombosis, that is the essential factor of cardiovascular events, for example myocardial infarction, cerebral infarction, and renal atrophy. Therefore, it is considerably significant for the early recognition and precise therapy of plaque. Biomimetic nanoparticles (BNPs), especially those coated with cell membranes, can retain the biological function of cell membranes or cells, which has led to extensive research and application in the diagnosis and treatment of AS in recent years. In this review, we summarized the roles of various key cells in AS progression, the construction of biomimetic nanoparticles based on these key cells as well as their applications in AS diagnosis and therapy. Furthermore, we give a challenge and prospect of biomimetic nanoparticles in AS, hoping to elevate their application quality and the possibility of clinical translation.
