Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One-pot fabrication of high-strength Janus hydrogel for wet tissue hemostasis and intestinal/intrauterine anti-adhesion.

Nature communications·2026
Same author

Approaching Scarless Wound Healing: From Passive Anti-Fibrotic to Proactive and Programmable Pro-Regenerative Strategies.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis.

Journal of cellular and molecular medicine·2025
Same author

Photo-Cross-Linked and Photothermal <i>Flammulina velutipes</i> Polysaccharide Hydrogel Loaded with Caffeic Acid-Copper Nanozyme for Diabetic Wound Healing.

ACS applied materials & interfaces·2025
Same author

Tri-Layer Citrate-Based Hydroxyapatite Composite Scaffold Promoting Osteogenesis and Gingival Tissue Regeneration for Periodontal Bone Defect Repair.

Advanced healthcare materials·2025
Same author

An HRL-SC/HIF-1α positive feedback loop enhances cell proliferation, migration and angiogenesis in dental pulp stem cells via PI3K/AKT signalling pathway.

International endodontic journal·2025

Related Experiment Video

Updated: Jun 16, 2025

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers
05:16

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers

Published on: February 9, 2024

651

An Optimized Decellularized Extracellular Matrix from Dental Pulp Stem Cell Sheets Promotes Axonal Regeneration by

Wei Qiu1, Bangyi Zhou1, Yifei Luo2

  • 1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.

Advanced Healthcare Materials
|August 16, 2024
PubMed
Summary

Decellularized extracellular matrix from dental pulp stem cells promotes neural regeneration after spinal cord injury. This biomaterial aids nerve repair and restores motor function in rats.

Keywords:
decellularized extracellular matrixdental pulp stem cellsneural regenerationneural stem cellsspinal cord injury

More Related Videos

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.2K
Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
08:05

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

7.0K

Related Experiment Videos

Last Updated: Jun 16, 2025

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers
05:16

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers

Published on: February 9, 2024

651
Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.2K
Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
08:05

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

7.0K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Extracellular matrix (ECM) is crucial for neural regeneration post-spinal cord injury (SCI).
  • Dental pulp stem cells (DPSCs) are accessible, secrete neurotrophic factors, and produce ECM, making them suitable for SCI treatment.
  • DPSC-derived ECM offers a promising acellular therapeutic option for SCI.

Purpose of the Study:

  • To investigate the efficacy of decellularized ECM derived from DPSC sheets (DPSC dECM) for treating SCI.
  • To optimize the decellularization process for DPSC sheets.
  • To elucidate the underlying mechanisms of DPSC dECM in promoting neural repair.

Main Methods:

  • Optimization of DPSC dECM preparation using 1% Triton X-100 for 5 minutes.
  • Administration of DPSC dECM to rats with SCI.
  • Assessment of nerve regeneration, hindlimb motor function recovery, neural stem cell behavior, microglial polarization, and glial scar formation.

Main Results:

  • DPSC dECM significantly promotes nerve repair and regeneration in SCI models.
  • Treatment with DPSC dECM restores hindlimb motor function in rats.
  • DPSC dECM enhances neural stem cell migration and differentiation, promotes M2 microglial polarization, and inhibits glial scar formation.

Conclusions:

  • DPSC dECM is a viable acellular biomaterial for promoting neural regeneration after SCI.
  • The therapeutic effects of DPSC dECM involve modulation of the cellular microenvironment and immune response.
  • DPSC dECM represents a promising strategy for future SCI therapies.