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Tri-Layer Citrate-Based Hydroxyapatite Composite Scaffold Promoting Osteogenesis and Gingival Tissue Regeneration for
Wei Qiu1, Kaiying Zhang1, Min Wu2
1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.
Advanced Healthcare Materials
|April 2, 2025
Summary
A new citrate-based hydroxyapatite scaffold effectively treats periodontal bone defects. This tri-layered material promotes bone regeneration, acts as a barrier, and enhances wound healing, showing promise for dental applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Periodontology
Background:
- Periodontal bone defects (PBD) require advanced regenerative materials with osteogenic, barrier, and wound healing capabilities.
- Citrate enhances bone formation and wound healing through osteoinductivity and angiogenesis.
Purpose of the Study:
- To develop and evaluate a novel tri-layered citrate-based hydroxyapatite (Ci-HA) composite scaffold for PBD treatment.
- To assess the osteogenic, barrier, and wound healing potential of Ci-HA.
Main Methods:
- A "one-pot" method was used to synthesize the tri-layered Ci-HA scaffold.
- In vitro studies assessed cell differentiation and gene expression of Ci-HA degradation products.
- In vivo evaluation was conducted in a rat periodontal intrabony defect model.
Main Results:
- Ci-HA degradation products promoted osteoblastic differentiation and angiogenesis-related gene expression.
- The intermediate layer of the Ci-HA scaffold demonstrated optimal barrier function in vitro.
- In vivo, Ci-HA significantly increased bone formation, osseointegration, and wound healing, comparable to commercial products.
Conclusions:
- The novel tri-layered Ci-HA composite scaffold exhibits high biocompatibility and multi-functional properties for PBD treatment.
- Ci-HA shows potential as a promising biomaterial for bone regeneration, barrier function, and wound healing in periodontal therapy.
Keywords:
barrierosteogenesisperiodontal tissue regenerationsoft tissue wound healingtri‐layered citrate‐based hydroxyapatite composite scaffoldMore Related Videos
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