Highly efficient electrocatalytic oxidation of levodopa as a Parkinson therapeutic drug based on modified
Tan Wang1, Nadhir N A Jafar2, Afrah Majeed Ahmed Al-Rihaymee3
1Three Gorges University, College of Basie Medical Scienees, 443002, China.
Abstract:
The current study presents the creation of a straightforward and sensitive sensor based on ZnO/Co3O4 nanocomposite modified screen-printed electrode (ZnO/Co3O4NC/SPE) for levodopa determination. At ZnO/Co3O4NC/SPE, an oxidative peak for levodopa solution in pH 6.0 phosphate buffer solution (PBS) were seen that were both more resolved and more enhanced. Levodopa was measured using differential pulse voltammetry (DPV), which showed an excellent linear range (0.001-800.0 μM) and detection limit (0.81 nM). The presence of interference did not affect the electrochemical response of levodopa at ZnO/Co3O4NC/SPE, demonstrating high selectivity. Levodopa in a real samples have been successfully detected using the manufactured sensor.
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