Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deconstructing a behavioral state: parallel neural integrators control distinct features of an aversive behavioral state in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2026

Same author

Connectome simulations identify a central pattern generator circuit for fly walking.

bioRxiv : the preprint server for biology·2026

Same author

Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans.

Current biology : CB·2026

Same author

Neural sequences underlying directed turning in Caenorhabditis elegans.

Nature neuroscience·2026

Same author

StrIPETrack: a real-time, ROI-flexible tracking platform for high-throughput zebrafish behavior.

Biology open·2026

Same author

Deep neural networks to register and annotate cells in moving and deforming nervous systems.

eLife·2026

Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026

Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026

Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026

Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026

Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 16, 2025

C. elegans Tracking and Behavioral Measurement

C. elegans Tracking and Behavioral Measurement

Published on: November 17, 2012

Neural Sequences Underlying Directed Turning in C. elegans.

Talya S Kramer^1,2, Flossie K Wan¹, Sarah M Pugliese¹

¹Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

Biorxiv : the Preprint Server for Biology

|August 16, 2024

Summary

This summary is machine-generated.

Scientists discovered how the nematode Caenorhabditis elegans uses sequential neural activity and the neuromodulator tyramine for olfactory navigation and error-correcting turns.

More Related Videos

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools

Published on: December 16, 2015

Related Experiment Videos

Last Updated: Jun 16, 2025

C. elegans Tracking and Behavioral Measurement

C. elegans Tracking and Behavioral Measurement

Published on: November 17, 2012

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools

Published on: December 16, 2015

Area of Science:

Neuroscience
Computational Biology
Animal Behavior

Background:

Complex behaviors, such as navigation, depend on precisely sequenced motor outputs.
Understanding the brain-wide neural circuits integrating sensory information for motor sequencing is crucial but remains incomplete.

Purpose of the Study:

To characterize the neural circuit architecture governing olfactory navigation in the nematode *C. elegans*.
To elucidate the neural mechanisms underlying error-correcting turns during navigation.

Main Methods:

Whole-brain calcium imaging in *C. elegans*.
Cell-specific genetic perturbations.
Analysis of neural and motor sequences during navigation.

Main Results:

Identified stereotyped neural sequences underlying error-correcting turns.
Demonstrated that specific neurons in these sequences process sensory cues, predict turn direction, and drive motor output.
Revealed that the neuromodulator tyramine coordinates these sequential brain dynamics.

Conclusions:

Neuromodulation, specifically tyramine, acts on a defined neural architecture to generate sequential neural activity.
This process links sensory cues to motor actions, enabling effective navigation and error correction in *C. elegans*.