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A functional analysis of a resorbable citrate-based composite tendon anchor.

Arun Thirumaran1, Meletios-Nikolaos Doulgkeroglou1, Magesh Sankar1

  • 1Centre for Research in Medical Devices (CÚRAM), University of Galway, Ireland.

Bioactive Materials
|August 16, 2024
PubMed
Summary

A novel citrate-based composite (POC-HA) shows promise for tendon fixation. This biomaterial supports bone cell growth and exhibits excellent mechanical and osteogenic properties in vitro and in vivo.

Keywords:
CitrateCompositeOsteoinductiveTendon anchor

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Tendon fixation to bone is crucial for healing after trauma or degeneration.
  • Osteomimetic biomaterials enhance bone healing by promoting osteoinduction and osteoconduction.
  • Existing resorbable anchors often use poly(L-co-D,l-lactic acid) and tricalcium phosphate (PLDLA-TCP).

Purpose of the Study:

  • To investigate a novel citrate-based composite (poly(octamethylene citrate)-hydroxyapatite, POC-HA) as a biomaterial for tendon fixation.
  • To evaluate the in vitro and in vivo performance of the POC-HA composite for bone and tendon healing.

Main Methods:

  • In vitro studies utilized human Mesenchymal Stem Cells (hMSCs) to assess cell adhesion, proliferation, and osteogenic differentiation.
  • In vivo evaluation involved a sheep metaphyseal model to assess the tendon fixation device's regenerative potential.
  • Mechanical and osteogenic properties were compared to conventional PLDLA-TCP anchors.

Main Results:

  • POC-HA composite supported hMSC adhesion, growth, proliferation, and enhanced osteogenic markers (calcium deposition, alkaline phosphatase, gene expression).
  • In vivo studies demonstrated the regenerative and remodeling capabilities of the POC-HA tendon fixation device.
  • Citrate-based HA composites showed superior mechanical and osteogenic properties compared to PLDLA-TCP anchors.

Conclusions:

  • The citrate-based POC-HA composite is a mechanically robust, bioactive material suitable for tendon fixation.
  • POC-HA demonstrates significant potential for promoting osteoinduction and osteoconduction for enhanced tendon-to-bone healing.
  • This novel biomaterial offers improved performance over current resorbable tendon anchor devices.