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Updated: Jun 16, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia

Adeline Su Lyn Ng1,2,3, Ai Huey Tan4,5, Yi Jayne Tan1

  • 1Department of Neurology, National Neuroscience Institute, Singapore, Singapore.

Movement Disorders : Official Journal of the Movement Disorder Society
|August 16, 2024
PubMed
Summary

Genetic analysis of Southeast Asian progressive supranuclear palsy (PSP) patients revealed novel variants, with MAPT, GBA1, and OPTN being common. Findings suggest distinct genetic factors and overlap with other neurodegenerative diseases.

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