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Published on: September 17, 2013
A near-infrared light-driven Janus nanomotor for deep tumor penetration and enhanced tumor immunotherapy
Ke Ma1, Zelong Chen1, Kai Liang1
1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
Abstract:
A near-infrared light-driven Janus nanomotor is constructed by collagenase-coated gold nanorods and chitosan-functionalized mesoporous organosilica nanoparticles with Mn2+ as the bridging ion. The nanomotors with excellent motility and collagenase activity can potently penetrate into tumors to sufficiently activate innate immune responses, significantly enhancing anti-tumor immune efficacy in vivo.
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