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Progress of heparanase in septic cardiomyopathy: A review

Di Chen1, Lin-Jun Wang1, Hong-Lei Li1

  • 1The First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, P. R. China.

Medicine
|August 16, 2024
PubMed

Insights

Heparanase (HPA) may significantly contribute to septic cardiomyopathy (SCM), a serious sepsis complication. This study explores HPA's role in SCM pathogenesis, offering new insights into diagnosis and treatment.

Area of Science:

  • Cardiology
  • Biochemistry
  • Pathophysiology

Background:

  • Septic cardiomyopathy (SCM) is a severe sepsis complication with high mortality.
  • Existing SCM mechanisms include endocardial injury, microcirculation issues, mitochondrial dysfunction, and fibrosis.

Purpose of the Study:

  • To investigate the potential role of heparanase (HPA) in the pathogenesis of septic cardiomyopathy.
  • To provide a novel perspective on SCM mechanisms, diagnosis, and treatment.

Main Methods:

  • Literature review and synthesis of pathophysiological changes related to HPA in SCM.
  • Analysis of HPA's known functions in inflammation, coagulation, and tissue remodeling.

Main Results:

  • Heparanase is implicated in inflammation, immune response, coagulation, microcirculation disturbance, mitochondrial dysfunction, and fibrosis.
  • These functions align with known SCM pathogenic pathways.

Conclusions:

  • Heparanase is hypothesized to play a critical role in the development of septic cardiomyopathy.
  • Understanding HPA's involvement may lead to improved diagnostic and therapeutic strategies for SCM.

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