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233
Pediatric mandibular malignancies: a comprehensive analysis of SEER data
S L Newman1, N B Drury2, K T Lee1
1Medical College of Georgia, Augusta University, Augusta, GA, USA.
International Journal of Oral and Maxillofacial Surgery
|August 16, 2024
Summary
Pediatric mandibular malignancies are rare. Advanced
Area of Science:
- Pediatric Oncology
- Skeletal Tumors
- Epidemiology
Background:
- Mandibular malignancies are uncommon in children, leading to limited characterization.
- Understanding survival factors is crucial for improving outcomes in this rare patient group.
Purpose of the Study:
- To analyze survival outcomes for pediatric mandibular malignancies.
- To identify prognostic factors influencing overall survival (OS) and disease-specific survival (DSS).
Main Methods:
- Utilized SEER 18 registry data for patients aged 0-18 years with ICD-O-3 code C41.1.
- Performed univariate Cox regression and Kaplan-Meier analysis for OS and DSS.
- Evaluated patient demographics, tumor characteristics, and treatment modalities.
Main Results:
- Osteosarcoma was the most frequent diagnosis (n=22).
- No significant association found between demographics, histology, or treatment and survival.
- A 'distant' SEER stage significantly increased hazard ratios for DSS (HR=6.28) and OS (HR=5.29).
- Kaplan-Meier curves showed significantly lower 5-year DSS and OS for the 'distant' stage.
Conclusions:
- Advanced stage at diagnosis is a critical negative prognostic factor for pediatric mandibular malignancies.
- Early detection and intervention are essential for improving survival rates in these rare tumors.
