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Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
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Chronic Obstructive Pulmonary Disease-V: Management01:29

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
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Tonsillitis II: Management01:26

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This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
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  11. Covid-19 Disease In Children With All Receiving Maintenance Therapy: Do Not Discount The Risk.
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Covid-19 Disease In Children With All Receiving Maintenance Therapy: Do Not Discount The Risk.

Related Experiment Video

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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COVID-19 Disease in Children With ALL Receiving Maintenance Therapy: Do Not Discount the Risk.

Alissa R Kahn1, Elizabeth S Davis2, Chen Dai3

  • 1Pediatric Hematology-Oncology, Department of Pediatrics, Saint Joseph's University Medical Center, Paterson, NJ.

JCO Oncology Practice
|August 19, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Children with acute lymphoblastic leukemia (ALL) in maintenance therapy (ALL-MTN) had fewer COVID-19 hospitalizations but required more treatment changes. COVID-19 vaccination reduced hospitalization risk in pediatric cancer patients.

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Area of Science:

  • Pediatric Oncology
  • Infectious Diseases
  • Hematology/Oncology

Background:

  • Children with acute lymphoblastic leukemia (ALL) in maintenance therapy (ALL-MTN) often resume normal activities, necessitating understanding of COVID-19's impact.
  • Physicians require data on persistent COVID-19 effects in pediatric cancer patients to guide families post-pandemic.

Purpose of the Study:

  • To compare the clinical course of COVID-19 in children with ALL-MTN versus other pediatric cancer patients.
  • To identify factors influencing COVID-19 outcomes in pediatric cancer.

Main Methods:

  • Data collected from the Pediatric Oncology COVID-19 Case Report (POCC) database, including sociodemographics and clinical information.
  • Analysis compared 481 children with ALL-MTN to 1,190 other pediatric cancer patients with COVID-19.
  • Multivariable analyses adjusted for age, race, insurance, neutrophil count, vaccination status, and comorbidities.

    • Main Results:

    • Children with ALL-MTN experienced significantly fewer hospitalizations (23% vs. 29%) and ICU admissions (3% vs. 5%) compared to other pediatric cancer patients.
    • However, cancer-directed therapy modifications were more frequent in the ALL-MTN group (50% vs. 33%).
    • COVID-19 vaccination was an independent factor, reducing hospitalization odds (OR, 0.7).

    Conclusions:

    • Pediatric patients with ALL-MTN had a less severe clinical course regarding hospitalization and ICU admission but required more frequent treatment adjustments.
    • COVID-19 vaccination demonstrated a protective effect, decreasing the likelihood of hospitalization in this cohort.