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Published on: June 7, 2015
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Initial treatment experience obtained with the real-time predictive motion tracking radiotherapy platform Synchrony:
Nathaniel Van Asselt1, Neil Christensen1
1Department of Surgical Sciences, University of Wisconsin Veterinary Care, Madison, Wisconsin, USA.
Summary
This pilot study explored Synchrony motion tracking for canine lung cancer radiation therapy. The system successfully treated pulmonary targets, showing promise for future oncological applications.
Area of Science:
- Veterinary Oncology
- Radiation Oncology
- Medical Physics
Background:
- Surgical excision is standard for primary pulmonary carcinomas and oligometastatic disease in dogs.
- Real-time predictive motion tracking offers potential for enhanced precision in radiotherapy.
- The Radixact radiotherapy device integrated with Synchrony aims to improve treatment accuracy.
Purpose of the Study:
- To evaluate the initial experience and feasibility of using the Synchrony real-time predictive motion tracking platform on the Radixact radiotherapy device.
- To assess Synchrony radiotherapy as an alternative to surgical excision for primary pulmonary carcinomas and oligometastatic disease in dogs.
- To investigate the efficacy and safety of Synchrony-guided radiotherapy in canine patients.
Main Methods:
- A pilot study involving dogs with primary pulmonary carcinomas or suspected oligometastatic disease.
- Synchrony real-time predictive motion tracking system mounted on the Radixact radiotherapy device.
- Treatment involved three fractions of 8 Gy, with analysis of cranial and diaphragmatic target movement.
- Evaluation of treatment success, side effects, and response via follow-up imaging.
Main Results:
- Six dogs with pulmonary targets were successfully treated with Synchrony radiotherapy.
- Abdominal targets with implanted fiducials could not be treated.
- Cranial targets exhibited minimal movement; diaphragmatic targets showed significant movement.
- No acute or late clinically apparent side effects were observed.
- One dog showed a strong partial response with minimal pneumonitis on follow-up imaging.
Conclusions:
- Synchrony motion tracking on the Radixact device is feasible for treating pulmonary targets in dogs.
- The system's efficacy for abdominal targets requires further investigation.
- Radiation therapy using Synchrony showed a good safety profile and potential efficacy in canine patients.
- Further investigation into Synchrony motion tracking for efficacy in veterinary radiotherapy is warranted.
