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Perspectives on donor-derived infections from the Notify Library.

Oscar Len1,2, Melissa A Greenwald3,4,5, Aurora Navarro6

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Transplant Infectious Disease : an Official Journal of the Transplantation Society
|August 20, 2024
PubMed
Summary

Preventing donor-derived infections (DDI) in medical products of human origin (MPHO) requires vigilant donor evaluation and biovigilance. The Notify Library aids physicians by cataloging serious adverse reactions and events (SARE) to enhance transplantation safety.

Keywords:
Donor‐derived infectionsbiovigilancemedical products of human origin

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Area of Science:

  • Transplantation Science
  • Infectious Disease Epidemiology
  • Biomedical Safety

Background:

  • Donor-derived infections (DDI) pose an inherent risk in medical products of human origin (MPHO) transplantation.
  • Mitigating DDI transmission necessitates rigorous donor evaluation and continuous vigilance by healthcare professionals.
  • Emerging infections require ongoing awareness and adaptation of safety protocols.

Purpose of the Study:

  • To highlight the importance of systematic donor evaluation in preventing DDIs.
  • To introduce the Notify Library as a didactic tool for managing serious adverse reactions and events (SARE) in MPHO.
  • To emphasize the role of biovigilance in ensuring MPHO safety.

Main Methods:

  • Systematic monitoring of serious adverse reactions and events (SARE) through biovigilance.
  • Utilizing the Notify Library, a database of 2808 references on SARE, primarily from published literature and surveillance programs.
  • Continuous updating of the Notify Library with new SARE records, particularly novel incidents.

Main Results:

  • The Notify Library provides comprehensive records of SARE, with a significant focus on DDIs in transplantation.
  • This resource serves as a valuable tool for assessing transplantation-associated SARE.
  • The library is dynamically updated, reflecting the evolving landscape of infectious incidents.

Conclusions:

  • Physician vigilance and a systematic approach to donor evaluation are crucial for mitigating DDI risks.
  • The Notify Library is an essential educational and practical tool for physicians, biovigilance activities, and the international scientific community.
  • Sharing lessons learned from SARE incidents improves organ donation processes and elevates quality and safety standards in transplantation.