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Design and implementation of a cost-effective, open-source, and programmable pulsatile flow system.

Sanna E Herwald1, Daniel Y Sze1, Daniel B Ennis1,2

  • 1Stanford University School of Medicine, Department of Radiology, 300 Pasteur Drive, Stanford, CA 94305, United States.

Hardwarex
|August 20, 2024
PubMed
Summary

Researchers developed a low-cost, open-source pulsatile flow system using an Arduino microcontroller to accurately simulate vascular blood flow. This adaptable platform offers a cost-effective alternative to commercial systems.

Keywords:
Arterial waveformProgrammable pulsatile pumpPulse waveform simulationVascular flow

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Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Open-Source Hardware

Background:

  • Accurate simulation of vascular blood flow is crucial for research and medical device development.
  • Commercial pulsatile flow systems are often expensive and lack adaptability.
  • There is a need for cost-effective, programmable solutions for simulating arterial flows.

Purpose of the Study:

  • To design, implement, and validate a programmable open-source pulsatile flow system.
  • To achieve cost-effective simulation of vascular flows using accessible materials.
  • To create an adaptable platform for replicating arterial pulse waveforms.

Main Methods:

  • Utilized an Arduino-compatible microcontroller and motor driver.
  • Controlled a centrifugal direct current (DC) motor pump for flow generation.
  • Programmed the system to produce pulsatile flows mimicking arterial waveforms.
  • Validated system performance using Doppler ultrasound and direct flow measurements.

Main Results:

  • The Arduino-based system successfully generated pulsatile flows with arterial waveforms.
  • Doppler ultrasound and flow measurements confirmed accurate replication of vascular flow.
  • The total bill of materials was as low as $99, demonstrating high cost-effectiveness.
  • The system proved adaptable and superior to commercial offerings in cost and flexibility.

Conclusions:

  • The developed open-source pulsatile flow system is a highly cost-effective and adaptable solution for simulating vascular flows.
  • This platform provides researchers with an accessible tool for studying hemodynamics and testing medical devices.
  • The successful validation highlights the potential of open-source hardware in biomedical research.