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Outcome of Corynebacterial Bloodstream Infection in Patients With Cardiac Implantable Electronic Devices: A Brief

Supavit Chesdachai1, Larry M Baddour1,2, M Rizwan Sohail1,3

  • 1Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Open Forum Infectious Diseases
|August 20, 2024
PubMed

Insights

Corynebacterial bloodstream infection (BSI) can lead to cardiac implantable electronic device infections, especially with persistent infections or prosthetic valves. Further research is needed to understand this association better.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Device Infections

Background:

  • Cardiac implantable electronic device (CIED) infections are a serious complication.
  • Corynebacterial bloodstream infections (BSI) are not fully understood in relation to CIED infections.

Purpose of the Study:

  • To investigate the occurrence and characteristics of CIED infections in patients with corynebacterial BSI.

Main Methods:

  • Retrospective review of patients diagnosed with corynebacterial BSI at Mayo Clinic between 2012 and 2023.
  • Analysis of patient data including infection episodes, presence of prosthetic cardiac valves, and BSI source.

Main Results:

  • Four out of 12 patients with corynebacterial BSI developed CIED infections.
  • One patient experienced CIED infection during a relapsing BSI episode.
  • Common features included undefined BSI source, persistent BSI, and prosthetic cardiac valves.

Conclusions:

  • Corynebacterial BSI poses a risk for CIED infection.
  • Persistent BSI and prosthetic cardiac valves are associated risk factors.
  • Further investigation is warranted to elucidate the pathophysiology and optimize management.

Keywords:
Corynebacteriumbloodstream infectioncardiac implantable electronic deviceinfectionrelapse

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