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Updated: May 5, 2026

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Clinical characteristics and outcomes of perinatal stroke in Australia: Population-based longitudinal study

Bithi Roy1,2,3, Annabel Webb4, Karen Walker5,6

  • 1Children's Hospital Westmead Clinical School, The University of Sydney, Sydney, New South Wales, Australia.

Journal of Paediatrics and Child Health
|August 20, 2024
PubMed

Insights

Early detection of perinatal stroke is crucial for preventing lifelong disability. This study highlights diverse symptoms and outcomes in Australian children, emphasizing the need for timely diagnosis and intervention.

Area of Science:

  • Neurology
  • Pediatrics
  • Public Health

Background:

  • Perinatal stroke is a leading cause of childhood hemiplegia and seizures.
  • Early identification of perinatal stroke is vital for mitigating long-term neurological deficits.

Purpose of the Study:

  • To analyze the clinical characteristics and outcomes of perinatal stroke in Australian children.
  • To improve early detection strategies for perinatal stroke.

Main Methods:

  • A population-based prospective longitudinal study was conducted.
  • The study included children up to 2 years of age, from 2017 to 2019.

Main Results:

  • Eighty-seven children with perinatal stroke were analyzed, with 79% acute and 21% presumed.
  • Acute symptomatic strokes often presented within 3 days of birth, while presumed strokes appeared by 6 months.
  • Cerebral palsy incidence was 29% for acute symptomatic and 72% for presumed perinatal stroke.

Conclusions:

  • The first week of life is critical for preventing disability from perinatal stroke.
  • Recognizing varied clinical presentations, including respiratory symptoms and asymptomatic cases, is key for early diagnosis.
  • Timely intervention based on early diagnosis can improve outcomes for children with perinatal stroke.
Abstract

Keywords:
cerebral palsyperinatal strokeseizures

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