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Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Sociology

Background:

  • Extensive research links occupation to cognitive skills.
  • Limited studies explore how genetically predicted cognition influences occupational choices.

Purpose of the Study:

  • To investigate the association between Cognitive Polygenic Index (PGI) and occupational complexity.
  • To determine if brain measures mediate the relationship between PGI and occupation.

Main Methods:

  • Utilized data from the Reference Ability Neural Network and Cognitive Reserve studies.
  • Assessed occupational complexity using Dictionary of Occupational Titles (Data, People, Things).
  • Employed linear regression with Cognitive PGI, adjusting for age, sex, education, genetic PCs, and brain measures (cortical thickness, gray matter volume).

Main Results:

  • Higher Cognitive PGI was significantly associated with higher Data occupational complexity (lower score implies higher complexity).
  • This association remained significant after adjusting for brain morphometry.
  • No significant associations were found for People or Things occupational complexity.

Conclusions:

  • Cognitive genes are associated with occupational complexity, independent of brain morphometry.
  • Occupational complexity involving Data may require higher cognitive status, which can be genetically influenced.