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Cognitive Polygenic Index is Associated with Occupational Complexity over and above Brain Morphometry
A Tsapanou1, N Mourtzi2, Y Gu1
1Department of Neurology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Behavior Genetics
|August 20, 2024
Summary
Genetically predicted cognitive ability influences occupation, particularly roles involving data. This association persists even after accounting for brain structure, suggesting a direct genetic link to occupational complexity.
Area of Science:
- Neuroscience
- Behavioral Genetics
- Sociology
Background:
- Extensive research links occupation to cognitive skills.
- Limited studies explore how genetically predicted cognition influences occupational choices.
Purpose of the Study:
- To investigate the association between Cognitive Polygenic Index (PGI) and occupational complexity.
- To determine if brain measures mediate the relationship between PGI and occupation.
Main Methods:
- Utilized data from the Reference Ability Neural Network and Cognitive Reserve studies.
- Assessed occupational complexity using Dictionary of Occupational Titles (Data, People, Things).
- Employed linear regression with Cognitive PGI, adjusting for age, sex, education, genetic PCs, and brain measures (cortical thickness, gray matter volume).
Main Results:
- Higher Cognitive PGI was significantly associated with higher Data occupational complexity (lower score implies higher complexity).
- This association remained significant after adjusting for brain morphometry.
- No significant associations were found for People or Things occupational complexity.
Conclusions:
- Cognitive genes are associated with occupational complexity, independent of brain morphometry.
- Occupational complexity involving Data may require higher cognitive status, which can be genetically influenced.
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