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Elafin level in lichen planus.

Reham William Doss¹, Esraa Hatem Ahmed Mohammed², Eman Hamdy Mohamed³

¹Dermatology Department, Faculty of Medicine, Beni-Suef University, Mohammed Hassan Street, Beni Suef, Beni- Suef, 62511, Egypt. reham.doss@med.bsu.edu.eg.

Archives of Dermatological Research

|August 20, 2024

Summary

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Elafin levels are significantly elevated in patients with lichen planus (LP), an autoimmune skin condition. This finding suggests elafin may play a role in the inflammatory processes involved in LP pathogenesis.

Area of Science:

Immunodermatology
Autoimmune diseases
Host defense proteins

Background:

Lichen planus (LP) is a chronic, inflammatory, autoimmune disorder affecting skin and mucous membranes.
Elafin, an epithelial host-defense protein, is upregulated in inflamed skin and other inflammatory skin conditions.
The specific role of elafin in lichen planus pathogenesis remains unclear.

Purpose of the Study:

To investigate the serum levels of elafin in patients with lichen planus.
To determine the association between elafin levels and lichen planus.
To explore the potential role of elafin in the pathogenesis of lichen planus.

Main Methods:

A case-control study was conducted with 30 lichen planus patients and 30 healthy controls.

Keywords:

Autoimmune diseases Lichen planus Pathogenesis

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Serum elafin levels were quantified using the enzyme-linked immunosorbent assay (ELISA) technique.

Statistical analysis was performed to compare elafin levels between groups.

Main Results:

Serum elafin levels were significantly higher in lichen planus patients compared to healthy controls (mean values 32.56 vs. 5.60, p < 0.001).
The elevated elafin levels indicate a strong association between elafin and lichen planus.
A statistically significant difference was observed, highlighting elafin's potential involvement.

Conclusions:

Elafin is significantly overexpressed in the serum of lichen planus patients.
Elafin may be implicated as a component of the inflammatory and autoimmune processes in lichen planus.
Further research is warranted to elucidate the precise mechanisms of elafin in LP.