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Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis
Christina M Lockwood1,2, Jason D Merker3,4, Elizabeth Bain5
1Association for Molecular Pathology, Rockville, Maryland, USA.
Clinical Pharmacology and Therapeutics
|August 21, 2024
Summary
The BLOODPAC consortium
Area of Science:
- Biomarker Discovery
- Translational Research
- Genomics
Background:
- BLOODPAC is a consortium focused on liquid biopsy research.
- They previously established 11 preanalytical minimal technical data elements (MTDEs).
Purpose of the Study:
- To evaluate the concordance of BLOODPAC MTDEs with existing liquid biopsy guidelines.
- To assess the suitability of BLOODPAC MTDEs for research and clinical applications.
Main Methods:
- Landscape analysis of current best practices, guidelines, and standards.
- Comparison of these documents with the 11 BLOODPAC preanalytical MTDEs.
Main Results:
- High concordance observed between BLOODPAC MTDEs and existing liquid biopsy standards.
- BLOODPAC MTDEs represent a minimal, practicable set for data collection.
Conclusions:
- BLOODPAC MTDEs align well with current liquid biopsy best practices.
- Recommended for use in data commons submissions and liquid biopsy trials globally.
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