Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.7K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.7K
Speciation Rates01:07

Speciation Rates

21.1K
Overview
21.1K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.2K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.2K
Cell Migration01:09

Cell Migration

17.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.0K
Migration00:53

Migration

7.9K
Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
7.9K
Design Example: Design of an Irrigation Channel01:27

Design Example: Design of an Irrigation Channel

82
Trapezoidal channels are widely used in irrigation systems due to their cost-effectiveness and efficiency in conveying water. Trapezoidal channels feature a flat bottom and sloping sides, making them stable and easier to construct compared to other shapes. The bottom width and side slope ratio are determined based on the required flow capacity and site conditions. The side slope is kept gentle for unlined channels to prevent soil erosion.Hydraulic parameters in channel design include the flow...
82

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomimetic MXene nanoplatform for tumor-specific synergistic phototherapy and immune reprogramming in pancreatic cancer.

Biomaterials science·2026
Same author

Therapeutic effects of hemoperfusion in treating long-acting anticoagulant rodenticide poisoning.

Blood purification·2026
Same author

Exploiting Device Deformability for Fluid and Particle Manipulation.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

The dual role of the CXCL9/10/11-CXCR3 axis in the tumor immune microenvironment: Mechanisms, therapeutic implications, and clinical translation.

Pharmacological research·2026
Same author

Diffuse endobronchial polyposis associated with chlorosilane inhalation.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

Convection enhanced phase change composite fibers for advanced thermal management.

Nature communications·2026
Same journal

Modeling the Effects of Short-Range Randomness in Packed Sphere Beds.

Analytical chemistry·2026
Same journal

Mitochondrial Redox Cascade-Directed Covalent NIR Fluorogenic Imaging of Therapy-Induced Senescence Integrates Tumor and Host Responses.

Analytical chemistry·2026
Same journal

Proteomic Profiling of RHD-Related Mitral Annulus Calcification Enabled by Magnetic Carbon Nanomaterial-Supported Quasi-Immobilized Enzyme Digestion.

Analytical chemistry·2026
Same journal

Spatial-Photonic Encoding on a Single Fiber: Breaking the Bottleneck in Photoelectrochemical Biosensing for Precision Diagnostics.

Analytical chemistry·2026
Same journal

Spreadable Biosensing Pregel for Analyte Visualization in Peeled Plant Tissues.

Analytical chemistry·2026
Same journal

DARibo-Q: RNA Allosteric Transduction for Fluorescence Imaging of Dopamine Modulation in Living Systems.

Analytical chemistry·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2025

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

11.9K

Deciphering the Evolution of Inertial Migration in Serpentine Channels.

Yong Liu1,2, Jun Zhang3,4, Xiaobo Peng2

  • 1Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.

Analytical Chemistry
|August 21, 2024
PubMed
Summary
This summary is machine-generated.

Particle migration in serpentine channels involves two stages, influenced by secondary flow. Understanding this mechanism aids in developing advanced particle separation technologies for diagnostics and screening.

More Related Videos

Evolution of Staircase Structures in Diffusive Convection
07:28

Evolution of Staircase Structures in Diffusive Convection

Published on: September 5, 2018

6.5K
Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

25.3K

Related Experiment Videos

Last Updated: Jun 16, 2025

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

11.9K
Evolution of Staircase Structures in Diffusive Convection
07:28

Evolution of Staircase Structures in Diffusive Convection

Published on: September 5, 2018

6.5K
Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

25.3K

Area of Science:

  • Fluid dynamics
  • Microfluidics
  • Biomedical engineering

Background:

  • Serpentine channels utilize inertial and secondary flows for particle focusing and separation.
  • Unclear inertial migration mechanisms in these channels hinder their application in diagnostics and drug screening.

Purpose of the Study:

  • To model and elucidate the effect of secondary flow on particle migration in serpentine channels.
  • To refine the understanding of inertial migration mechanisms for improved particle separation.

Main Methods:

  • Direct numerical simulation (DNS) to compute inertial lift.
  • Lagrangian particle tracking (LPT) to analyze particle migration.
  • Experimental validation of the numerical model for microparticle migration.

Main Results:

  • Particle migration in serpentine channels exhibits a two-stage process.
  • Increased secondary flow accelerates the second migration stage and slows the first.
  • Established guidelines for high-resolution particle separation by analyzing parameter effects.

Conclusions:

  • The study clarifies the inertial migration mechanism in serpentine channels.
  • Findings provide a foundation for inertial particle separation in microfluidic devices.
  • Dimensionless analysis enables the separation of particles of various sizes, considering flow resistance.