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Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
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Relationship between inflammatory markers, hormonal profiles, and sperm parameters.

Muserref Banu Yilmaz1, Reyyan Gokcen Iscan1, Zeynep Celik1

  • 1Department of Obstetrics and Gynecology, University of Health Sciences, Zeynep Kamil Women and Children's Disease Training and Research Hospital, Istanbul, Turkiye.

Northern Clinics of Istanbul
|August 21, 2024
PubMed
Summary

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels negatively correlate with sperm quality. White blood cell (WBC) and neutrophil counts show a positive correlation with sperm parameters, suggesting potential inflammatory markers for further research.

Keywords:
FSHLHneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiosemen parameters

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Area of Science:

  • Reproductive Endocrinology
  • Andrology
  • Hematology

Background:

  • Semen quality is crucial for male fertility.
  • Complete blood count (CBC) and hormone levels may influence sperm parameters.
  • Understanding these relationships can aid in diagnosing and managing male infertility.

Purpose of the Study:

  • To investigate the correlation between semen parameters, CBC, and hormone levels.
  • To determine the predictive value of CBC-derived ratios for sperm quality.

Main Methods:

  • Analysis of semen parameters, CBC, and hormone levels from 230 male patients.
  • Patients were categorized based on total motile sperm count (TMSC).
  • Statistical comparisons were made between different patient groups.

Main Results:

  • No significant difference in neutrophil-to-lymphocyte (N/L) or platelet-to-lymphocyte (P/L) ratios across groups.
  • Weak positive correlations observed between white blood cell (WBC) and lymphocyte counts with sperm concentration and motility.
  • Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were negatively correlated with sperm concentration, motility, and TMSC.

Conclusions:

  • FSH and LH levels are significantly negatively associated with sperm concentration, motility, and TMSC.
  • N/L and P/L ratios are not reliable predictors of sperm quality.
  • Positive correlations between WBC/neutrophil counts and sperm parameters warrant further investigation in larger, prospective studies.