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Updated: Jun 16, 2025

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Reductive Amination of Aldehyde and Ketone with Ammonia and H2 by an In Situ-Generated Cobalt Catalyst under Mild
Shiyun Zhang1,2, Yue Hu2, Meichao Li1
1College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Abstract:
Herein, we present the simplest approach for the synthesis of primary amines via reductive amination using H2 as a reductant and aqueous ammonia as a nitrogen source, catalyzed by amorphous Co particles. The highly active Co particles were prepared in situ by simply mixing commercially available CoCl2 and NaBH4/NaHBEt3 without any ligand or support. This reaction system features mild conditions (80 °C, 1-10 bar), high selectivity (99%), a wide substrate scope, simple operation, and easy separation of the catalyst. The successful large-scale application of this reaction in the production of primary amines suggests its potential industrial interest.
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