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Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
Published on: November 10, 2017
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Luminescent photon-upconversion nanoparticles with advanced functionalization for smart sensing and imaging
1Department of Biochemistry, Faculty of Science, Masaryk University, Kamenice, 5, 625 00, Brno, Czech Republic. skladal@chemi.muni.cz.
Mikrochimica Acta
|August 21, 2024
Summary
Photon-upconversion nanoparticles (UCNP) are advanced labels for bioassays and imaging. Smart UCNP systems offer temporal and spatial control for intracellular monitoring and cancer theranostics.
Area of Science:
- Nanotechnology
- Biotechnology
- Materials Science
Background:
- Photon-upconversion nanoparticles (UCNP) are established labels for affinity assays.
- Advanced UCNP systems incorporate active shells, dyes, and nanoparticles for energy transfer.
Purpose of the Study:
- To review advanced UCNP systems for bioanalytical assays and imaging.
- To highlight progress in UCNP applications, including intracellular monitoring and cancer theranostics.
Main Methods:
- Review of UCNP systems with active shells and energy transfer components.
- Integration of switching elements for temporal and spatial control.
- Critical analysis of representative UCNP approaches in bioanalysis and imaging.
Main Results:
- Demonstration of smart UCNP systems with enhanced functionalities.
- UCNPs enable precise temporal and spatial control for intracellular applications.
- Successful application of UCNPs in bioanalytical assays, imaging, and cancer theranostics.
Conclusions:
- Advanced UCNP systems offer significant potential for sophisticated bioanalytical tools.
- Smart UCNPs are crucial for intracellular imaging and monitoring.
- UCNPs are promising for the advancement of cancer theranostics.
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