Current and Novel Treatment Options in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative

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Nerea Lopetegui-Lia1, Revati Varma2, Jame Abraham1

  • 1Cleveland Clinic, Cleveland, OH.

JCO Oncology Practice
|August 21, 2024
PubMed

Insights

Metastatic breast cancer treatment is advancing with novel targeted therapies. Optimizing drug sequencing and shared decision-making are crucial for improving patient outcomes.

Area of Science:

  • Oncology
  • Medical Genetics

Background:

  • Metastatic breast cancer (mBC) is largely incurable, with most patients experiencing disease progression.
  • Endocrine therapy is standard for hormone receptor-positive/human epidermal growth factor receptor 2-negative mBC, but new treatments are emerging.

Purpose of the Study:

  • To review advancements in mBC treatment.
  • To highlight the role of molecular markers and targeted agents.
  • To address challenges in drug sequencing and treatment decisions.

Main Methods:

  • Review of current literature on mBC therapeutics.
  • Analysis of novel targeted agents and their mechanisms.
  • Discussion of treatment sequencing strategies.

Main Results:

  • Significant progress in mBC treatment through targeted agents like antibody-drug conjugates and PI3K/AKT/mTOR inhibitors.
  • Improved survival and quality of life for patients with mBC.
  • Emergence of challenges in selecting optimal drug sequences.

Conclusions:

  • Personalized medicine approaches are transforming mBC care.
  • Genomic data and shared decision-making are essential for effective treatment planning.
  • Further research is needed to refine drug sequencing in mBC.

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