Related Experiment Video

Updated: Jun 15, 2025

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.1K

Predictive Value of D-Dimer for In-Hospital Mortality in Non-Diabetic Patients with Non-ST-segment Elevation

Bin Li1,2, Xiaojing Liu3, Miaomiao Gao3

  • 1Department of Cardiology, The Seventh People's Hospital of Zhengzhou & Henan Key Laboratory of Cardiac Remodeling and Transplantation, Zhengzhou, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|August 22, 2024
PubMed

Insights

Elevated D-dimer levels predict in-hospital death in non-diabetic patients with non-ST-segment elevation myocardial infarction (NSTEMI). This biomarker is linearly associated with mortality risk, offering a reliable prognostic tool.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Prognosis

Background:

  • Elevated D-dimer is a known predictor of mortality across various diseases.
  • The prognostic value of D-dimer in non-ST-segment elevation myocardial infarction (NSTEMI) remains under investigation.
  • Non-diabetic NSTEMI patients require clear prognostic indicators for in-hospital outcomes.

Purpose of the Study:

  • To investigate the association between D-dimer levels and in-hospital mortality in non-diabetic patients with NSTEMI.
  • To compare the predictive performance of D-dimer, albumin (ALB), and D-dimer to albumin ratio (DAR) for in-hospital death.
  • To explore the nature of the relationship between D-dimer and mortality risk using restricted cubic spline analysis.

Main Methods:

  • Retrospective analysis of 662 non-diabetic NSTEMI patients.
  • Multivariate logistic regression to identify independent risk factors for in-hospital mortality.
  • Receiver operating characteristic (ROC) curve analysis to assess predictive values of D-dimer, ALB, and DAR.
  • Restricted cubic spline (RCS) modeling to evaluate linear/nonlinear associations between D-dimer and mortality.

Main Results:

  • In-hospital mortality was observed in 5.7% of patients.
  • D-dimer was identified as an independent predictor of in-hospital mortality (OR=1.19, P=0.036).
  • D-dimer showed significant predictive performance (AUC=0.75), comparable to ALB and DAR, for in-hospital mortality.
  • RCS analysis revealed a linear relationship between D-dimer levels and the risk of in-hospital death (P for nonlinear=0.747).

Conclusions:

  • D-dimer is a valuable and reliable biomarker for predicting in-hospital mortality in non-diabetic patients with NSTEMI.
  • The association between D-dimer and mortality risk in this population is linear.
  • D-dimer can aid in risk stratification and clinical decision-making for NSTEMI patients.

Keywords:
D-dimer to albumin ratioNSTEMIalbuminbiomarkerlinear

More Related Videos

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.4K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

380

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
119
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
228
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
68