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Updated: Jun 15, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

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Oncogenic roles of long non-coding RNAs in essential glioblastoma signaling pathways

Mina Lashkarboloki1, Amin Jahanbakhshi2, Seyed Javad Mowla1

  • 1Genetics Department, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Journal of Neurogenetics
|August 22, 2024
PubMed

Insights

Glioblastoma multiforme (GBM), a deadly brain cancer, is driven by oncogenic long non-coding RNAs (lncRNAs). Targeting these lncRNAs offers a promising new strategy for developing effective glioblastoma treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioblastoma multiforme (GBM) is an aggressive brain cancer with poor patient survival rates.
  • Current treatments have shown limited success, necessitating novel therapeutic strategies.
  • Dysregulation of oncogenes and tumor suppressor genes initiates carcinogenic pathways in GBM.

Purpose of the Study:

  • To identify and characterize oncogenic long non-coding RNAs (lncRNAs) involved in glioblastoma multiforme (GBM) pathogenesis.
  • To explore the potential of lncRNAs as diagnostic, prognostic, and therapeutic targets for GBM.
  • To classify identified oncogenic lncRNAs based on the signaling pathways they regulate.

Main Methods:

  • Literature review and analysis of existing studies on lncRNAs in glioblastoma.
  • Identification of key oncogenic lncRNAs implicated in GBM development and progression.
  • Classification of lncRNAs according to their regulated target genes and associated signaling pathways.

Main Results:

  • Multiple oncogenic lncRNAs were identified as significant contributors to GBM.
  • These lncRNAs play critical roles in regulating gene transcription, translation, and epigenetic modifications.
  • The study classified these oncogenic lncRNAs into distinct signaling pathways relevant to glioblastoma.

Conclusions:

  • Oncogenic lncRNAs are crucial players in glioblastoma multiforme (GBM) carcinogenesis.
  • lncRNAs represent promising biomarkers for GBM diagnosis and prognosis.
  • Targeting oncogenic lncRNAs presents a potential novel therapeutic avenue for treating glioblastoma.
Keywords:
GlioblastomaLong non-coding RNAOncogenicSignal Transduction

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