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Non-Equilibrium Dissipative Assembly with Switchable Biological Functions.

Peng Zhao1, Yuanfeng Zhao1, Yan Lu1

  • 1School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210, Shanghai, China.

Angewandte Chemie (International Ed. in English)
|August 22, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel cytomembrane-like dissipative assembly (DSA) system using chiral supramolecules. This fuel-driven system mimics biological functions, enabling programmable shifts for enhanced fibroblast interactions and efficient, recyclable drug delivery.

Keywords:
Dissipative self-assemblychiral supramoleculesfuel-driven drug deliverynanofiber-nanosphere transitionout of equilibrium systems

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Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry
  • Synthetic Biology

Background:

  • Natural dissipative assemblies (DSAs) exhibit dynamic, energy-driven functional shifts, a trait rare in synthetic counterparts.
  • Mimicking these biological transformations in artificial systems is crucial for developing advanced materials.
  • Chiral supramolecular chemistry offers a pathway to create complex, responsive synthetic assemblies.

Purpose of the Study:

  • To engineer a synthetic dissipative assembly (DSA) system that mimics cytomembrane-like functions.
  • To demonstrate programmable, fuel-induced shifts in the assembly's structure and bioactivity.
  • To establish a novel, recyclable drug delivery vehicle based on bioactive DSAs.

Main Methods:

  • Utilized benzoyl cysteine derivatives to form chiral supramolecular M-helix nanofibers under equilibrium conditions.
  • Investigated the interaction of these nanofibers with fibroblast cells, assessing adhesion and proliferation.
  • Introduced chemical fuels to induce a temporary transformation of nanofibers into nanospheres for drug delivery, followed by self-reversion.

Main Results:

  • Chiral supramolecular nanofibers promoted fibroblast adhesion and proliferation via stereospecific interactions.
  • Addition of chemical fuels triggered a reversible transformation from nanofibers to nanospheres.
  • The nanosphere formation facilitated efficient, fuel-driven drug delivery with subsequent material recycling.

Conclusions:

  • The developed cytomembrane-like DSA system demonstrates programmable function-shifting capabilities.
  • This represents a novel, fuel-driven drug delivery vehicle with self-recycling properties.
  • The study advances synthetic DSAs for biological applications and paves the way for 'living' materials.